Recent Publications

Mast Cells

• What do mast cells "Mast Cell Activation Disorder" have to do with pain, fatigue, allergies and even autism?  Click the blogtalkradio logo button below to listen to the answer.
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DIAGNOSIS & TREATMENT

Children with Autism Spectrum Disorders

 

Autism

Autism Drugs in Wealthy Nations

Elevated serum neurotensin and CRH levels in children with
autistic spectrum disorders...

Extracellular Mitochondrial ATP, Suramin ,and Autism?
Extracellular Mitochondrial Components Secreted from Activated Live Mast Cells Act as “Innate Pathogens” and Contribute to Autism Pathogenesis
The “missing link” in autoimmunity and autism: Extracellular mitochondrial components secreted from activated live mast cells
Focal Brain Inflammation and Autism
NeuroProtek - 2012
Autism, Seizures, JNI 2012
Autism, Allergies JADD
Inflammatory Conditions (Quicktime video)
The Immune System & Autism (Quicktime/Flash Video)
Novel therapeutic targets for autism
Mast cells as targets of corticotropin releasing factor and related peptides
Critical role of mast cells in inflammatory diseases and
the effect of acute stress

Autism: an emerging ‘neuroimmune disorder’ in search of therapy
Autism Spectrum Disorders and Mastocytosis
Mercury induces inflammatory mediator release from human mast cells
Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children
Neurotensin is increased in serum of young children with autistic disorder

 

Brain Health

Stress Blood Brain Barrier
Brain Inflammation
Non-steroidal Drugs Inhibit SSRI Antidepressant Action
Mast Cells - The Immune Gate to the Brain

 

Fibromyalgia / Chronic Fatigue

Fibromyalgia - New Concepts Of Pathogenesis And Treatment


Interstitial Cystitis

Interstitial Cystitis Bladder Pain Syndrome
When to Suspect Interstitial Cystitis
Inflammatory Conditions (Quicktime video)
CystoProtek® (video)
Increased Numbers of Activated Mast Cells in Endometriosis Lesions Positive for Corticotropin-Releasing Hormone and Urocortin
Treatment of refractory interstitial cystitis/
painful bladder syndrome with CystoProtek
– an oral multi-agent natural supplement

A Pilot Open Label Study Of Cystoprotek In Interstitial Cystitis
New agents for the medical treatment of interstitial cystitis
Interstitial cystitis: bladder pain and beyond
Acute Stress and Intravesical Corticotropin-Releasing Hormone Induces Mast Cell Dependent Vascular Endothelial Growth Factor Release From Mouse Bladder Explants
Intravesical Nanocrystalline Silver Decreases Experimental Bladder Inflammation
Intravesical Suplatast Tosilate (IPD-1151T) Inhibits Experimental Bladder Inflammation
The Mast Cell in Interstitial Cystitis: Role in
Pathophysiology and Pathogenesis

Immunomodulators For Treatment Of Interstitial Cystitis

 

Arthritis

Mast cells and mast cell mediators as targets of dietary supplements
Chondroitin sulphate inhibits connective tissue mast cells
Mast Cell Deficient W/Wv Mice Lack Stress-Induced Increase In Serum Il-6 Levels, As Well As In Peripheral Crh And Vascular Permeability, A Model Of Rheumatoid Arthritis
Dietary Supplements For Arthritis And Other Inflammatory Conditions: Key Role Of Mast Cells And Benefit Of Combining Anti-Inflammatory And Proteoglycan Products


Mastocytosis

The Mast Cell: A Cell for All Seasons
Quercetin Better Than Cromolyn
CRH, BBB-Bioscience Differential release of mast cell mediators and the pathogenesis of inflammation
Neuroimmunoendocrine circuitry of the ‘brain-skin connection’
Secondary Anetoderma Associated with Mastocytosis
Acute Stress-Induced Seizures and Loss of Consciousnenn in a Ten-Year-Old Boy With Cutaneous Mastocytosis
Urticaria pigmentosa associated with acute stress and lesional skin mast-cell expression of CRF-R1


Skin Diseases

Natural remedy may stop psoriasis flares before they start

Impact of Mast Cells on the Skin

Regulation of corticotropin-releasing hormone receptor-2 expression in human cord blood-derived cultured mast cells
Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process
Human Mast Cells Express Corticotropin-Releasing Hormone (CRH) Receptors and CRH Leads to Selective Secretion of Vascular Endothelial Growth Factor
Corticotropin-Releasing Hormone Induces Vascular Endothelial Growth Factor Release from Human Mast Cells via the cAMP/Protein Kinase A/p38 Mitogen-Activated Protein Kinase Pathway
Acute Stress Results in Skin Corticotropin- Releasing Hormone Secretion, Mast Cell Activation and Vascular Permeability, an Effect Mimicked by Intradermal Corticotropin- Releasing Hormone and Inhibited
by Histamine-1 Receptor Antagonists

Skin Corticotropin-Releasing Hormone Receptor Expression in Psoriasis
IL-33 augments substance P–induced VEGF secretion
from human mast cells and is increased in psoriatic skin

Corticotropin-Releasing Hormone Receptor-1 and Histidine Decarboxylase Expression in Chronic Urticaria
A Quercetin Containing Supplement Reduces Niacin-Induced Flush In Humans
Rupatadine Inhibits Proinflammatory Mediator Secretion from Human Mast Cells Triggered by Different Stimuli
Neuroimmunoendocrine circuitry of the 'brain-skin connection'
Potent Mast Cell Degranulation and Vascular Permeability Triggered by Urocortin Through Activation of Corticotropin- Releasing Hormone Receptors
Urticaria pigmentosa associated with acute stress and lesional skin mast-cell expression of CRF-R1

 

Multiple Sclerosis

IJIP MS Hydroxyzine
Luteolin, MS, TCT, J Neuroinflam 11-09
Luteolin, T cells, mast cells BJP 2008
Monkey EAE
Mast Cells The Immune Gate to the Brain LIfe Sciences 1990
MBB, estradiol activate brain mast cells, demyelination, Neuroscience

 

Cancer

Mast cells and pancreatic cancer
Mast cells: the JEKYLL and HYDE of tumor growth
Brain metastases of mouse mammary adenocarcinoma is increased by acute stress
Impact of stress and mast cells on brain metastases
Mast Cells and Tumor Microenvironment


Brain Inflammation

Brain Inflammation, Neuropsychiatric Disorders, and Immunoendocrine Effects of Luteolin
Histochemical and Ultrastructural Characteristics of Rat Barin Perivascular Mast Cell Stimulated With Compound 48/80 and Carabachol
Definitive Characterization of Rat Hypothalamic Mast Cells
The role of mast cells in migraine pathophysiology
Corticotropin-releasing hormone and the blood-brain-barrier
Corticotropin-Releasing Hormone and Brain Mast Cells Regulate Blood-Brain-Barrier Permeability Induced by Acute Stress
Definitive Characterization of Rat Hypothalamic Mast Cells
Nasal provocation of patients with allergic rhinitis and the hypothalamic-pituitary-adrenal axis
Critical role of mast cells in inflammatory diseases and the effect of acute stress
Acute stress increases permeability of the blood–brain-barrier through activation of brain mast cells
Non-invasive assessment of blood–brain barrier (BBB) permeability using a gamma camera to detect 99technetium-gluceptate extravasation in rat brain
Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice

 

Cardiovascular Diseases

Mast cells squeeze the heart and stretch the gird
Stress triggers coronary mast cells leading to cardiac events

The Role of Mast Cells in Acute Coronary Syndromes
Sites of Interleukin-6 Release in Patients With Acute Coronary Syndromes and in Patients With Congestive Heart Failure
Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in Apolipoprotein E knockout mice
IL-1 Induces Vesicular Secretion of IL-6 without Degranulation from Human Mast Cells
Kounis Syndrome (Allergic Angina and Allergic Myocardial Infarction)
Coronary Stents, Hypersensitivity Reactions, and the Kounis Syndrome
The flavonoid luteolin inhibits niacin-induced flush
Allergic Inflammation and Adipocytokines
The flavonoid luteolin inhibits niacin-induced flush
Niacin-induced "Flush" Involves Release of Prostaglandin D2 from Mast Cells and Serotonin from Platelets: Evidence from Human Cells in Vitro and an Animal Model
Mast Cell Deficient W/W Mice Have Lower Serum IL-6 and Less Cardiac Tissue Necrosis Than Their Normal Littermates Following Myocardial Ischemia-Reperfusion
Mast cell tryptase: a new biomarker in patients with stable coronary artery disease
Mast cell tryptase: a new biomarker in patients with stable coronary artery disease
Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kB activation


Flavonoids

Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells
Flavones inhibit proliferation and increase mediator content in human leukemic mast cells (HMC-1)
The Effects of Plant Flavonoids on Mammalian Cells:
Implications for Inflammation, Heart Disease,
and Cancer

The Isoflavone Genistein Inhibits Proliferation and Increases Histamine Content in Human Leukemic Mast Cells
The flavonoid luteolin inhibits niacin-induced flush
Luteolin as a therapeutic option for multiple sclerosis
Luteolin inhibits myelin basic protein-induced human mast cell activation and mast cell-dependent stimulation of Jurkat T cells
The flavonoid luteolin inhibits niacin-induced flush

 

Mast Cells and Inflammation

Mast Cells in Meningiomas and Brain Inflammation

Methoxyluteolin Inhibits Neuropeptide-stimulated Proinflammatory Mediator Release via mTOR Activation from Human Mast Cellss

Neuroendocrinology of Mast Cells

Vitamin D and Atopy

Antihistamines and Mental Status

Mast cells and inflammation
Use of Polyphenols in Periodontal Inflammation

Differential release of mast cell mediators and the pathogenesis of inflammation
Critical role of mast cells in inflammatory diseases and the effect of acute stress
The Critical Role of Mast Cells in Allergy and Inflammation

 

Migraines

The role of mast cells in migraine pathophysiology
Corticotropin-releasing hormone and the blood-brain-barrier
Morphological and functional demonstration of rat dura mater mast cell–neuron interactions in vitro and in vivo
Nasal provocation of patients with allergic rhinitis and the hypothalamic-pituitary-adrenal axis
Corticotropin-Releasing Hormone and Its Structurally Related Urocortin Are Synthesized and Secreted by Human Mast Cells
Mast Cells: The Immune Gate To The Brain
Migraine Headaches: The Immunologist's View
Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice
Stress-Induced Intracranial Mast Cell Degranulation: A Corticotropin-Releasing Hormone-Mediated Effect
Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice
Mast cells as targets of corticotropin- releasing factor and related peptides

 

pathogenesis

Neuroinflammation and Autism

 

 

ALLERGY & ASTHMA

Contribution of stress to asthma worsening through mast cell activation
Do Mast Cells Link Obesity and Asthma?
•  Mast Cells in Allergic and Inflammatory Diseases

A probable case report of stress-induced anaphylaxis

 

IRRITABLE BOWEL SYNDROME

Mast Cells in Irritable Bowel Syndrome and Ulcerative Colitis

 

TRIGEMINAL

Trigeminal nerve stimulation triggers oral mast cell activation and vascular permeability

 

 

Relevant recent reviews (2010 - 2011) include:

 

Pandolfi F, Cianci R, Cammarota G, Pagliari D, Landolfi R, Conti P, Theoharides TC. Recent insights in primary immunodeficiency diseases: the role of T-lymphocytes and innate immunity. Ann Clin Lab Sci 40(1):3-9, 2010.

 

Manola, A., Kourelis, T., Angelidou A, Theoharides, TC. Mast cell mediators and inflammatory diseases. In Kounis Syndrome: The Coronary Hypersensitivity Syndrome (Nicholas G. Kounis, ed.). Nova Science Publishers: Hauppauge, N.Y, 2010.

 

Kourelis, T., Manola, A., Alysandratos K-D, Theoharides, TC. Mast cell activation. In Kounis Syndrome: The Coronary Hypersensitivity Syndrome (Nicholas G. Kounis, ed.). Nova Science Publishers: Hauppauge, N.Y, 2010.

 

Castellani ML, Anogeianaki A, Felaco P, Toniato E, De Lutiis MA, Shaik B, Fulcheri M, Vecchiet J, Tetè S, Salini V, Theoharides TC, Caraffa A, Antinolfi P, Frydas I, Conti P, Cuccurullo C, Ciampoli C, Cerulli G, Kempuraj D. IL-35, an anti-inflammatory cytokine which expands CD4+CD25+ Treg Cells. J Biol Regul Homeost Agents 24(2):131-5, 2010.

 

Castellani ML, De Lutiis MA, Toniato E, Conti F, Felaco P, Fulcheri M, Theoharides TC, Caraffa A, Antinolfi P, Conti P, Cuccurullo C, Ciampoli C, Felaco M, Orso C, Salini V, Cerulli G, Kempuraj D, Tetè S, Shaik B. Impact of RANTES, MCP-1 and IL-8 in mast cells. J Biol Regul Homeost Agent 24(1):1-6, 2010.

 

Castellani ML, Felaco P, Galzio RJ, Tripodi D, Toniato E, De Lutiis MA, Fulcheri M, Caraffa A, Antinolfi P, Tete S, Felaco M, Conti F, Pandolfi F, Theoharides TC, Shaik-Dasthagirisaheb YB. IL-31 a Th2 cytokine involved in immunity and inflammation. Int J Immunopathol Pharmacol 23(3):709-13, 2010.

 

Castellani ML, Galzio RJ, Felaco P, Tripodi D, Toniato E, De Lutiis MA, Conti F, Fulcheri M, Conti C, Theoharides TC, Caraffa A, Antinolfi P, Felaco M, Tete S, Pandolfi F, Shaik-Dasthagirisaheb YB. VEGF, substance P and stress, new aspects: a revisited study. J Biol Regul Homeost Agents 24(3):229-37, 2010.

 

Castellani ML, Anogeianaki A, Felaco P, Toniato E, De Lutiis MA, Shaik B, Fulcheri M, Vecchiet J, Tetè S, Salini V, Theoharides TC, Caraffa A, Antinolfi P, Frydas I, Conti P, Cuccurullo C, Ciampoli C, Cerulli G, Kempuraj D. IL-35, an anti-inflammatory cytokine which expands CD4+CD25+ Treg Cells. J Biol Regul Homeost Agents 24(2):131-5, 2010. 52

 

Castellani ML, De Lutiis MA, Toniato E, Conti F, Felaco P, Fulcheri M, Theoharides TC, Caraffa A, Antinolfi P, Conti P, Cuccurullo C, Ciampoli C, Felaco M, Orso C, Salini V, Cerulli G, Kempuraj D, Tetè S, Shaik B. Impact of RANTES, MCP-1 and IL-8 in mast cells. J Biol Regul Homeost Agents 24(1):1-6, 2010.

 

Castellani ML, Galzio RJ, Felaco P, Tripodi D, Toniato E, De Lutiis MA, Conti F, Fulcheri M, Conti C, Theoharides TC, Caraffa A, Antinolfi P, Felaco M, Tete S, Pandolfi F, Shaik-Dasthagirisaheb YB. VEGF, substance P and stress, new aspects: a revisited study. J Biol Regul Homeost Agents 24(3):229-37, 2010.

 

Castellani ML, Felaco P, Galzio RJ, Tripodi D, Toniato E, De Lutiis MA, Fulcheri M, Caraffa A, Antinolfi P, Tetè S, Felaco M, Conti F, Pandolfi F, Theoharides TC, Shaik-Dasthagirisaheb YB. IL-31 a Th2 cytokine involved in immunity and inflammation. Int J Immunopathol Pharmacol 23(3):709-13, 2010.

 

Anogeianaki A, Castellani ML, Tripodi D, Toniato E, DeLutiis MA, Conti F, Felaco P, Fulcheri M, Theoharides TC, Galzio R, Caraffa A, Antinolfi P, Cuccurullo C, Ciampoli C, Felaco M, Cerulli G, Pandolfi F, Sabatino G, Neri G, Shaik-Dasthagirisaheb YB. Vitmains and mast cells. Int J Immunopathol Pharmacol, in press, 2010.

 

Angelidou A, Alysandratos K-D, Asadi S, Zhang B, Francis K, Vasiadi M, Kalogeromitros D, Theoharides TC. Neonatal mast cell activation and autism. More than meets the eye? J Autism Dev Disorders, in press, 2011.

 

Whitmore, K.., Theoharides, T.C., Interstitial cystitis/bladder pain syndrome. J Family Practice, in press, 2011.

 

Theoharides TC, Angelidou A, Alysandratos K-D, Zhang BD, Asadi S, Francis K, Toniato E, Kalogeromitros D. Mast cell activation and autism. Biochim Biophys Acta. 2011, in press.

 

Theoharides TC, Angelidou A, Alysandratos K-D, Zhang BD, Sismanopoulos N, Delivane D, Vasiadi M, Asadi S, Miniati A, Kalogeromitros D. Mast cells and inflammation. Biochim Biophys Acta. 2011, in press.

 

Theoharides, T.C. Kourembanas, S. Perinatal stress and risk for autism. In preparation.

 

Alysandratos K-D, Angelidou A, Papadimas E, Dizon P, Theoharides TC. Stress gets the lungs sqeezing and wheezing. In preparation.

 

 

 

 

upcoming events
16September

Nashville Support Group Meeting - Saturday, September 16, 2017
10a-4p Hermitage Library, 3700 James Kay Lane, Hermitage, TN 37076
Speaker: Dr. Theoharides, MD

 

 

21October

Brain Fires in Autism: Mast Cells, Microglia and Brain Inflammation
Hilton Orange County Hotel in Costa Mesa, BELIEVE room 2 – 8:00AM

 

 

22October

Stress, Brain Inflammation and Brain Fog in Autism
Hilton Orange County Hotel in Costa Mesa, BELIEVE room 2 – 8:00AM

 

 

11November

Bari (Italy), 2nd European Conference of Biomedical Research and Treatments of Autism - Mast cell-microglia connection leading to focal inflammation of the brain in autism
Saturday @ 15.40
Brochure (PDF)

 

 

30November

Queen Mary University of London,
15:30-15:30-Regulatory systems pathway from stress to disease and possible parallels to periodontal disease
Email: a.b.o.gamboa@qmul.ac.uk

 

 

30November

Queen Mary University of London,
15:30-16:00-Interventions on the immune regulatory systems
Email: a.b.o.gamboa@qmul.ac.uk

 

 

01December
02December

Conway Hall, London, 10:00 am,
Role of Mast Cells in Inflammatory Diseases

 

 

Prof. Theoharides' Invited Lectures (2015-16)

  • • Australia Autism Lecture (April 24, 2015; Melbourne, Australia)
  • • Boston Conservatory of Music (May 5, 2015; Boston, MA)
  • • Autism Education Summit (September 26, 2015; Dallas, TX)
  • • National Autism Association (October 15, 2015; St. Pete, FL)
  • • Autism Research Institute (December 5, 2015; Boston, MA, 2015)
  • • Cyprus Pediatric Association (February 14, 2016; Nicosia, CY)
  • • TARF Think Tank (February 19, 2016; Boston, MA)
  • • NCIMS (February 27, 2016;Greenboro, NC)
  • • TACA Massachusetts (March 12, 2016; Watertown MA)
  • • 11th PanHellenic Conference on Allergy & Clinical Immunology (April 16, 2016; Athens, Greece)
  • • TACA Webinar (April 25, 2016; 1 pm)
  • • All Childrens Hospital (April 1, 2016; St. Pete, FL)
  • • TACA Philadelphia (May 7, 2016; Philadelphia, PA)
  • • Autism One (May 27, 2016; Chicago, IL)
  • • Autism One Think Tank (May 28, 2016; Chicago, IL)
  • • EAAACI (June 7-11, 2017; Vienna, Austria)
  • • Old North State Medical Society (June 23-25, 2016; Raleigh, NC)
  • • FASEB Summer Research Conference in the long-running Neuroimmunology series entitled "Translational Neuroimmunology: From Mechanisms to Therapeutics" (July 24-29, 2016; Big Sky, MT)
  • • 11th Annual USAAA World Autism and Asperger Conference (August 29, 2016; Louisville, KY)
  • • MAPS Conference (September 9, 2016; Atlanta, GA)
  • • The Mastocytosis Society (September 15-17, 2016; Orlando, FL)
  • • International College of Geriatric Psychoneuropharmacology (ICGP) (October 7, 2016; Athens, Greece)
  • • TACA National Conference (October 22, 2016; Costa Mesa, CA)
  • • ILADS Annual meeting (November 4, 2016; Philadelphia, PA)
  • • 37th UMEMPS (Union of Middle-Eastern and Mediterranean Pediatric Societies-Cyprus Pediatric Society (November 6, 2016; Limassol, Cyprus)
  • • 1st International Conference on Autism (November 22, 2016; Paphos, Cyprus)

EAAACI=European Academy of Allergy and Clinical Immunology
ILADS=International Lyme and Associated Diseases Society
MAPS=Medical Academy of Pediatrics  Se-0pcial Needs
NCIMS=North Carolina Integrative Medical Society
TARF=The Autism Research Foundation
TACA=Think About Curing Autism
ILADS=International Lyme and Associated Diseases Society


 

 

 

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