Recent Pubicaions for Mast Cell Topics

• What do mast cells "Mast Cell Activation Disorder" have to do with pain, fatigue, allergies and even autism? Click the blogtalkradio logo button below to listen to the answer.

• Mast cells and pain, International Association for the Study of Pain

Mast Cells and Inflammation

• Podcast: Mast Cell Matters: Deep dives on MCAS

• Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

• Mast cells, Pancreatitis_2014

• Mast cell activation and microbiome

• Mast cell activation beyond histamine and tryptase Exp-Rev-Clin-Immunol_2023

• Mast cell activation disorders, Exp Rev Clin Immunol 2014

• Mast cell mediator disorder, Exp Rev Clin Imminol 2019

• Mast cell, obesity asthma, Allergy 2014

• Mast cells and COVID-19_medRxiv_2022

• Mast cells and SARS-CoV-2_NEJM, 2023

• Mast cells in allergy inflamm Curr Pharm Des 2012

• Mast cells brain inflammation and autism Eur J Pharmacol 2016

• Mast cells, COVID-19_Annals Allergy Asthma 2021

• Mast cells, dendritic cells_JACI 2021

• Mast cells, fear, autism, Intl J Mol Sci 2019

• Mast cells, FMS, pain, Front Cell Neurosci 2019

• Mast cells, IBS, Dig Dis Sc 2014

• Mast cells, IL-1 beta, PNAS 9-2018

• Mast cells, IL-37, Intl J Mol Sci, 2019

• Mast cells, Immunity_IJMS 2023

• Mast cells, inflammation, BBA 2012

• Mast cells, mastocytosis and supplemental, NEJM July 9, 2015

• Mast cells, meningiomas_J Neuroinflam, 2015

• Mast cells, migraines_Brain Res Rev, 2005

• Mast cells, MS, strress, Autoimm Rev, 2013

• Mast cells, neuroinflammation_Front Cell Neurosc, 2019

• Mast cells, neuron contacts, Clin Ther 2016 main

• Mast cells, obesity, MI, Trends Pharm Sc 2011

• Mast cells, pancreatic cancer_NEJM, 2008

• Mast cells, stress, asthma Ann Allergy Asthma Immunol 2012

• Mast cells, stress, fear, autism, Intl J Mol Sci 2019

• Mast cells, stress, heart, Ann Allergy Asthma Immunol 2014

• Mastocytose - fatigue

• Mastocytosis, cognitive impairment 2012

• Mast cell activation: beyond histamine and tryptase

• Substance P and IL-33 administered together stimulate a marked secretion...

• Danger Signals and Inflammation

• Neuropeptides and Inflammatory Cytokines Are Increased in Serum of Patients with Fibromyalgia Syndrome, Implicating Mast Cells.

• Fybromyalgia Syndrome in Need of Effective Treatments

• SP and IL-33 together markedly enhance TNF synthesis
and secretion from human mast cells mediated by the
interaction of their receptors

• Targeting IL-33 in Autoimmunity and Inflammation

• Mast Cells in Meningiomas and Brain Inflammation

• Methoxyluteolin Inhibits Neuropeptide-stimulated Proinflammatory Mediator Release via mTOR Activation from Human Mast Cellss

• Neuroendocrinology of Mast Cells

• Vitamin D and Atopy

• Antihistamines and Mental Status

• Mast cells and inflammation
• Use of Polyphenols in Periodontal Inflammation

• Differential release of mast cell mediators and the pathogenesis of inflammation
• Critical role of mast cells in inflammatory diseases and the effect of acute stress
• The Critical Role of Mast Cells in Allergy and Inflammation

Mastocytosis

• Spectrum of Mast Cell Activation Disorders

• Mast Cells, Mastocytosis and Related Disorders

• Neuroendocrinology of Mast Cells: Challenges and
Controversies

• The Mast Cell: A Cell for All Seasons
• Quercetin Better Than Cromolyn
• CRH, BBB-Bioscience Differential release of mast cell mediators and the pathogenesis of inflammation
• Neuroimmunoendocrine circuitry of the ‘brain-skin connection’
• Secondary Anetoderma Associated with Mastocytosis
• Acute Stress-Induced Seizures and Loss of Consciousnenn in a Ten-Year-Old Boy With Cutaneous Mastocytosis
• Urticaria pigmentosa associated with acute stress and lesional skin mast-cell expression of CRF-R1

Migraines

• The role of mast cells in migraine pathophysiology
• Corticotropin-releasing hormone and the blood-brain-barrier
• Morphological and functional demonstration of rat dura mater mast cell–neuron interactions in vitro and in vivo
• Nasal provocation of patients with allergic rhinitis and the hypothalamic-pituitary-adrenal axis
• Corticotropin-Releasing Hormone and Its Structurally Related Urocortin Are Synthesized and Secreted by Human Mast Cells
• Mast Cells: The Immune Gate To The Brain
• Migraine Headaches: The Immunologist's View
• Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice
• Stress-Induced Intracranial Mast Cell Degranulation: A Corticotropin-Releasing Hormone-Mediated Effect
• Stress-induced dura vascular permeability does not develop in mast cell-deficient and neurokinin-1 receptor knockout mice
• Mast cells as targets of corticotropin- releasing factor and related peptides

Multiple Sclerosis

• IJIP MS Hydroxyzine
• Luteolin, MS, TCT, J Neuroinflam 11-09
• Luteolin, T cells, mast cells BJP 2008
• Monkey EAE
• Mast Cells The Immune Gate to the Brain LIfe Sciences 1990
• MBB, estradiol activate brain mast cells, demyelination, Neuroscience

Pathogenesis

Neuroinflammation and Autism

Skin Diseases

• Natural remedy may stop psoriasis flares before they start

• Impact of Mast Cells on the Skin

• Regulation of corticotropin-releasing hormone receptor-2 expression in human cord blood-derived cultured mast cells
• Corticotropin-releasing hormone induces skin vascular permeability through a neurotensin-dependent process
• Human Mast Cells Express Corticotropin-Releasing Hormone (CRH) Receptors and CRH Leads to Selective Secretion of Vascular Endothelial Growth Factor
• Corticotropin-Releasing Hormone Induces Vascular Endothelial Growth Factor Release from Human Mast Cells via the cAMP/Protein Kinase A/p38 Mitogen-Activated Protein Kinase Pathway
• Acute Stress Results in Skin Corticotropin- Releasing Hormone Secretion, Mast Cell Activation and Vascular Permeability, an Effect Mimicked by Intradermal Corticotropin- Releasing Hormone and Inhibited
by Histamine-1 Receptor Antagonists
• Skin Corticotropin-Releasing Hormone Receptor Expression in Psoriasis
• IL-33 augments substance P–induced VEGF secretion
from human mast cells and is increased in psoriatic skin
• Corticotropin-Releasing Hormone Receptor-1 and Histidine Decarboxylase Expression in Chronic Urticaria
• A Quercetin Containing Supplement Reduces Niacin-Induced Flush In Humans
• Rupatadine Inhibits Proinflammatory Mediator Secretion from Human Mast Cells Triggered by Different Stimuli
• Neuroimmunoendocrine circuitry of the 'brain-skin connection'
• Potent Mast Cell Degranulation and Vascular Permeability Triggered by Urocortin Through Activation of Corticotropin- Releasing Hormone Receptors
• Urticaria pigmentosa associated with acute stress and lesional skin mast-cell expression of CRF-R1

SUPPLIMENTS

• Luteolin-rich fraction from Perilla frutescens seed meal inhibits spike glycoprotein S1 of SARS-CoV-2-induced NLRP3 inflammasome lung cell inflammation via regulation of JAK1/STAT3 pathway

• Luteolin Is More Potent than Cromolyn in Their Ability to Inhibit Mediator Release from Cultured Human Mast Cells

• Luteolin is a potential inhibitor of COVID-19

• Luteolin Hormonal Effects
• Luteolin, Post-Lyme s., 2016
• Luteolin, Long-COVID brain fog_Biofactors 2021
• Luteolin, MS_J Neuroinflamm 2009
• Luteolin, COVID-19, mast cells, cytokines_BioFactors 2020
• Luteolin- Neuropsychiatric Disorders
• Luteolin supplements- All that glitters is not gold_Biofactors 2020
• Methoxyluteolin, mast cells, JACI 2015
• Methoxyluteolin, mast cells, mTOR, JPET 2017
• Methlut lotion, Intl J Immunpath Pharm 2017

TRIGEMINAL

• Trigeminal nerve stimulation triggers oral mast cell activation and vascular permeability

Relevant recent reviews (2010 - 2011) include:

Pandolfi F, Cianci R, Cammarota G, Pagliari D, Landolfi R, Conti P, Theoharides TC. Recent insights in primary immunodeficiency diseases: the role of T-lymphocytes and innate immunity. Ann Clin Lab Sci 40(1):3-9, 2010.

Manola, A., Kourelis, T., Angelidou A, Theoharides, TC. Mast cell mediators and inflammatory diseases. In Kounis Syndrome: The Coronary Hypersensitivity Syndrome (Nicholas G. Kounis, ed.). Nova Science Publishers: Hauppauge, N.Y, 2010.

Kourelis, T., Manola, A., Alysandratos K-D, Theoharides, TC. Mast cell activation. In Kounis Syndrome: The Coronary Hypersensitivity Syndrome (Nicholas G. Kounis, ed.). Nova Science Publishers: Hauppauge, N.Y, 2010.

Castellani ML, Anogeianaki A, Felaco P, Toniato E, De Lutiis MA, Shaik B, Fulcheri M, Vecchiet J, Tetè S, Salini V, Theoharides TC, Caraffa A, Antinolfi P, Frydas I, Conti P, Cuccurullo C, Ciampoli C, Cerulli G, Kempuraj D. IL-35, an anti-inflammatory cytokine which expands CD4+CD25+ Treg Cells. J Biol Regul Homeost Agents 24(2):131-5, 2010.

Castellani ML, De Lutiis MA, Toniato E, Conti F, Felaco P, Fulcheri M, Theoharides TC, Caraffa A, Antinolfi P, Conti P, Cuccurullo C, Ciampoli C, Felaco M, Orso C, Salini V, Cerulli G, Kempuraj D, Tetè S, Shaik B. Impact of RANTES, MCP-1 and IL-8 in mast cells. J Biol Regul Homeost Agent 24(1):1-6, 2010.

Castellani ML, Felaco P, Galzio RJ, Tripodi D, Toniato E, De Lutiis MA, Fulcheri M, Caraffa A, Antinolfi P, Tete S, Felaco M, Conti F, Pandolfi F, Theoharides TC, Shaik-Dasthagirisaheb YB. IL-31 a Th2 cytokine involved in immunity and inflammation. Int J Immunopathol Pharmacol 23(3):709-13, 2010.

Castellani ML, Galzio RJ, Felaco P, Tripodi D, Toniato E, De Lutiis MA, Conti F, Fulcheri M, Conti C, Theoharides TC, Caraffa A, Antinolfi P, Felaco M, Tete S, Pandolfi F, Shaik-Dasthagirisaheb YB. VEGF, substance P and stress, new aspects: a revisited study. J Biol Regul Homeost Agents 24(3):229-37, 2010.

Castellani ML, Felaco P, Galzio RJ, Tripodi D, Toniato E, De Lutiis MA, Fulcheri M, Caraffa A, Antinolfi P, Tetè S, Felaco M, Conti F, Pandolfi F, Theoharides TC, Shaik-Dasthagirisaheb YB. IL-31 a Th2 cytokine involved in immunity and inflammation. Int J Immunopathol Pharmacol 23(3):709-13, 2010.

Anogeianaki A, Castellani ML, Tripodi D, Toniato E, DeLutiis MA, Conti F, Felaco P, Fulcheri M, Theoharides TC, Galzio R, Caraffa A, Antinolfi P, Cuccurullo C, Ciampoli C, Felaco M, Cerulli G, Pandolfi F, Sabatino G, Neri G, Shaik-Dasthagirisaheb YB. Vitmains and mast cells. Int J Immunopathol Pharmacol, in press, 2010.

Angelidou A, Alysandratos K-D, Asadi S, Zhang B, Francis K, Vasiadi M, Kalogeromitros D, Theoharides TC. Neonatal mast cell activation and autism. More than meets the eye? J Autism Dev Disorders, in press, 2011.

Whitmore, K.., Theoharides, T.C., Interstitial cystitis/bladder pain syndrome. J Family Practice, in press, 2011.

Theoharides TC, Angelidou A, Alysandratos K-D, Zhang BD, Asadi S, Francis K, Toniato E, Kalogeromitros D. Mast cell activation and autism. Biochim Biophys Acta. 2011, in press.

Theoharides TC, Angelidou A, Alysandratos K-D, Zhang BD, Sismanopoulos N, Delivane D, Vasiadi M, Asadi S, Miniati A, Kalogeromitros D. Mast cells and inflammation. Biochim Biophys Acta. 2011, in press.

Theoharides, T.C. Kourembanas, S. Perinatal stress and risk for autism. In preparation.

Alysandratos K-D, Angelidou A, Papadimas E, Dizon P, Theoharides TC. Stress gets the lungs sqeezing and wheezing. In preparation.

upcoming events

16-18 Mar

MAPS SPRING 2023
Functional & Translational Medicine Conferance MARCH 16-18, 2023 at Charlotte, NC
Event Website

4 Apr

FREE WEBINAR
Mast Cell Over-Activation, and How it Affects our Mind and Body Wellbeing
Thursday, April 4th 1:00 PM EDT | 19:00 (Copenhagen)
Location: Zoon
Send an email to mastcell@neurodiversitet.net about your participation. A Zoom link will be shared in response.

Greek Presentations

• Το σύνδρομο του Long Covid και η εξατομικευμένη προστασία από τον κορονοϊό

• Long Covid Syndrome και εξατομικευμένη προστασία από τον κορονοϊό

• Presentation 01 / PDF Details

Prof. Theoharides' Invited Lectures (2015-17)

• Australia Autism Lecture (April 24, 2015; Melbourne, Australia)
• Boston Conservatory of Music (May 5, 2015; Boston, MA)
• Autism Education Summit (September 26, 2015; Dallas, TX)
• National Autism Association (October 15, 2015; St. Pete, FL)
• Autism Research Institute (December 5, 2015; Boston, MA, 2015)
• Cyprus Pediatric Association (February 14, 2016; Nicosia, CY)
• TARF Think Tank (February 19, 2016; Boston, MA)
• NCIMS (February 27, 2016;Greenboro, NC)
• TACA Massachusetts (March 12, 2016; Watertown MA)
• 11th PanHellenic Conference on Allergy & Clinical Immunology (April 16, 2016; Athens, Greece)
• TACA Webinar (April 25, 2016; 1 pm)
• All Childrens Hospital (April 1, 2016; St. Pete, FL)
• TACA Philadelphia (May 7, 2016; Philadelphia, PA)
• Autism One (May 27, 2016; Chicago, IL)
• Autism One Think Tank (May 28, 2016; Chicago, IL)
• EAAACI (June 7-11, 2017; Vienna, Austria)
• Old North State Medical Society (June 23-25, 2016; Raleigh, NC)
• FASEB Summer Research Conference in the long-running Neuroimmunology series entitled "Translational Neuroimmunology: From Mechanisms to Therapeutics" (July 24-29, 2016; Big Sky, MT)
• 11th Annual USAAA World Autism and Asperger Conference (August 29, 2016; Louisville, KY)
• MAPS Conference (September 9, 2016; Atlanta, GA)
• The Mastocytosis Society (September 15-17, 2016; Orlando, FL)
• International College of Geriatric Psychoneuropharmacology (ICGP) (October 7, 2016; Athens, Greece)
• TACA National Conference (October 22, 2016; Costa Mesa, CA)
• ILADS Annual meeting (November 4, 2016; Philadelphia, PA)
• 37th UMEMPS (Union of Middle-Eastern and Mediterranean Pediatric Societies-Cyprus Pediatric Society (November 6, 2016; Limassol, Cyprus)
• 1st International Conference on Autism (November 22, 2016; Paphos, Cyprus)
• Nashville Support Group Meeting - Saturday, September 16, 2017 10a-4p Hermitage Library, 3700 James Kay Lane, Hermitage, TN 37076 Speaker: Dr. Theoharides, MD
• Brain Fires in Autism: Mast Cells, Microglia and Brain Inflammation - Hilton Orange County Hotel in Costa Mesa, BELIEVE room 2 – 8:00AM October 2017.
• Stress, Brain Inflammation and Brain Fog in Autism - Hilton Orange County Hotel in Costa Mesa, BELIEVE room 2 – 8:00AM October 2017
• Bari (Italy), 2nd European Conference of Biomedical Research and Treatments of Autism - Mast cell-microglia connection leading to focal inflammation of the brain in autism Saturday @ 15.40 - Brochure (PDF) November 2017
• Queen Mary University of London, 15:30-15:30-Regulatory systems pathway from stress to disease and possible parallels to periodontal disease Email: a.b.o.gamboa@qmul.ac.uk November 2017
• Queen Mary University of London, 15:30-16:00-Interventions on the immune regulatory systems Email: a.b.o.gamboa@qmul.ac.uk November 2017
• Conway Hall, London, 10:00 am, Brain Fires in Autism: Mast Cells, Microglia and Inflammation of the Brain December 2017
• Conway Hall, London, 10:00 am, Role of Mast Cells in Inflammatory Diseases December 2017

EAAACI=European Academy of Allergy and Clinical Immunology
ILADS=International Lyme and Associated Diseases Society
MAPS=Medical Academy of Pediatrics Se-0pcial Needs
NCIMS=North Carolina Integrative Medical Society
TARF=The Autism Research Foundation
TACA=Think About Curing Autism
ILADS=International Lyme and Associated Diseases Society

dietary supplements

Find useful dietary supplements based upon our work.

Dietary Supplement Advice

Luteolin supplements: All that glitters is not gold (PDF)
Algonot Supplements (PPT)

past event photos

TACA National Conference - October 20 - 22, 2017

research activities

Photos

Websites

www.gentlederm.com
www.brain-gate.org

How to Explain Autism to Children
https://indyschild.com/how-to-explain-autism-to-children/

Creating the Ultimate Sensory Room for Your Toddler
https://localbabysitter.com/creating-the-ultimate-sensory-room-for-your-toddler/