• Sharing the knowledge slide
  • Leading to Answers
  • From Science to Patient care slide
  • From Science to Patient care slide

Increase in autism reported by the CDC


Today, the Centers for Disease Control (CDC) published in  Morbidity and Mortality Weekly Report, its findings from the Autism and Developmental Disabilities Monitoring (ADDM) Network, an ongoing surveillance system that provides estimates on the prevalence of autism  spectrum disorder (ASD), that 1 in 54 children in the U.S. have an autism diagnosis, a 10% increase from its 2018 report.

Evidence indicates that post-COVID-19 symptoms are MultiSystem Inflammatory Syndrome or Mast cell Activation Syndrome, characterized by chronic fatigue and Brain Fog that could be prevented or minimized by luteolin.

Learn More & Additional COVID Resources




With thanks for help from Dr. Elizabeth Spaar, we put together these signs of shortness of breath you may look for in case someone is not able to communicate or is nonspeaking: 
·     Lethargy or unusual tiredness
·     Panting or loud breathing
·     Sucking in (retraction) at base of throat while inhaling
·     Sucking in (retraction) at the ribs, also during inhale
·     Belly breathing - seeing the stomach extended more than usual on inhale
·     Stomach muscles tensing while trying to push air out
·     Longer time to exhale than inhale
·     Tripod stance (leaning over with hands on knees)
·     Bluish nail beds or lips
·     Change of mental status/confusion
If you develop emergency warning signs for COVID-19 get medical attention immediately. Emergency warning signs include:
·     Difficulty breathing or shortness of breath
·     Persistent pain or pressure in the chest
·     New confusion or inability to arouse
·     Bluish lips or face 
More information can be found at the CDC's website


Mast Cell research

Pharmacology is the core of translational research leading to ways of alleviating disease. We study how mast cells are involved in allergy and inflammation. We showed that mast cells are activated by CRH and neurotensin secreted under stress to release inflammatory molecules selectively, including mitochondrial DNA ("innate pathogen") leading to disruption of the gut-blood-brain barriers and to inflammation. We have also shown that the flavonoid luteolin is inhibitory, and a patented liposomal formulation NeuroProtek®, benefits patients with allergies, autism and chronic fatigue syndrome...


Mast cell topics & recent publications

Here you will find over 100 publications from the Theoharides’ Lab relevant to his research in Pharmacology and Drug Development.


Awards & Honors

Awards and honors for Dr. Theoharides.


video presentations

A look into Dr. Theoharides’ lectures or interviews on various topics.




Lecture Slides

Follow along copies of slides Dr. Theoharides has lectured with.  Some may be used in conjunction with video lecture presentations or guides for research.


Clinical studies

Papers on past and present clinical studies.


Testimonials &
Useful Links

Kind words for Dr. Theoharides and his work.


Donations for our autism and mast cell research are critical. Please donate using the link below:

(all lower case letters)
Featured presentation

AUTISM - A Pharmacologist's View.


Learn more about T. C. Theoharides, MS, PhD, MD, FAAAAI

New "innate pathogens" discovered by Dr. Theoharides (PDF)


Recent News Media

Expertscape's PubMed-based algorithms placed Dr. Theoharides in the top 1% of scholars writing about Mastocytosis over the past 10 years, a level we label as "Expert." The following was announced on Twitter on Nov 9, 2021:


"During Healthy Skin Month (November 2021), we congratulate
Dr. Theoharis C Theoharides of Tufts University --
Recognized as an Expertscape Expert in Mastocytosis."



Potential Anti-inflammatory Treatment for Autism @ safeMinds





Greek Newspaper Article 2017 (PDF)


Greek Newspaper Article 2016 (PDF)


Groundbreaking Research Links Autism with Histamine, Inflammation and Mast Cell Activation. Read Article


Congratulations to Dr. Theoharides! The book Neuroimmune Pharmacology has recently been published in electronic and print format. Dr. Theoharids contributed to the Autism Spectrum Disorders portion of the book.


•• Dr. Theoharides paper "Neurotensin stimulates NTR3/sortilin and mTOR in human microglia: Potential therapeutic target in autism inhibitable by methoxyluteolin" has published online at www.pnas.org.


•• Dr. Theoharides selected to be included in "Famous Greeks"


•• Article on Dr. Theoharides' work on "BrainFog" in the Greek paper VIMA TIS KYRISKIS-SUNDAY SCIENCE edition (July 17, 2016)


•• Luteolin for mast cells, histamine and brain fog?


•• A wonderful plant supplement has been backed by scientific research as a mast cell stabiliser and antihistamine.

••  Hope For Autism - The National Herald

••  Autism Spectrum Programs at The Boston Conservatory

•• National Psoriasis Foundation - News Articles






My mystery symptoms and mast cells (documentary)



ARI-Brain Allergy and Autism



AutismOne 2016-An Autism Subgroup With Brain Inflammation Is Treatable



Interview with Dr. Theoharides on GREEK NATIONAL TV DIPLI MATIA on Autism and Brain Fog



Interview with Dr. Theoharides on CNN.gr on Brain Inflammation



Radio & Podcast Presentations

How to Make Friends With Your Immune System, the Latest Research on Autism, and Rethinking Antioxidant Supplements with Dr. Theoharis Theoharides. Listen to the Podcast




Interview of Dr. Theoharides by Mary Ann Rousso to The BlockTakRadio/Coffee Klatch/Special Needs Radio on Mast Cell Disorders.


Interview of Dr. Theoharides on intelligent radio by Dr. Hoffman on the benefits of luteolin.

upcoming events
9th Sept

Autism Parenting Presentation
September 9, 2021
Autism Parenting Magazine is pleased to host  Theoharis C. Theoharides, MS, MPhil, PhD, MD, FAAAAI, Professor of Pharmacology and Internal Medicine, Director of Molecular Immunopharmacology and Drug Discovery Department of Immunology, Tufts University School of Medicine,


8th Oct

Grand Rounds at MacMaster University - "Mast Cells:Beyond Histamine".
The event will at 12 Noon on a Free Zoom call.
Join Zoom Meeting
Meeting ID: 926 5244 8889
Passcode: 606916

Greek Presentations

Presentation 01 / PDF Details



Prof. Theoharides' Invited Lectures (2015-17)

  • • Australia Autism Lecture (April 24, 2015; Melbourne, Australia)
  • • Boston Conservatory of Music (May 5, 2015; Boston, MA)
  • • Autism Education Summit (September 26, 2015; Dallas, TX)
  • • National Autism Association (October 15, 2015; St. Pete, FL)
  • • Autism Research Institute (December 5, 2015; Boston, MA, 2015)
  • • Cyprus Pediatric Association (February 14, 2016; Nicosia, CY)
  • • TARF Think Tank (February 19, 2016; Boston, MA)
  • • NCIMS (February 27, 2016;Greenboro, NC)
  • • TACA Massachusetts (March 12, 2016; Watertown MA)
  • • 11th PanHellenic Conference on Allergy & Clinical Immunology (April 16, 2016; Athens, Greece)
  • • TACA Webinar (April 25, 2016; 1 pm)
  • • All Childrens Hospital (April 1, 2016; St. Pete, FL)
  • • TACA Philadelphia (May 7, 2016; Philadelphia, PA)
  • • Autism One (May 27, 2016; Chicago, IL)
  • • Autism One Think Tank (May 28, 2016; Chicago, IL)
  • • EAAACI (June 7-11, 2017; Vienna, Austria)
  • • Old North State Medical Society (June 23-25, 2016; Raleigh, NC)
  • • FASEB Summer Research Conference in the long-running Neuroimmunology series entitled "Translational Neuroimmunology: From Mechanisms to Therapeutics" (July 24-29, 2016; Big Sky, MT)
  • • 11th Annual USAAA World Autism and Asperger Conference (August 29, 2016; Louisville, KY)
  • • MAPS Conference (September 9, 2016; Atlanta, GA)
  • • The Mastocytosis Society (September 15-17, 2016; Orlando, FL)
  • • International College of Geriatric Psychoneuropharmacology (ICGP) (October 7, 2016; Athens, Greece)
  • • TACA National Conference (October 22, 2016; Costa Mesa, CA)
  • • ILADS Annual meeting (November 4, 2016; Philadelphia, PA)
  • • 37th UMEMPS (Union of Middle-Eastern and Mediterranean Pediatric Societies-Cyprus Pediatric Society (November 6, 2016; Limassol, Cyprus)
  • • 1st International Conference on Autism (November 22, 2016; Paphos, Cyprus)
  • • Nashville Support Group Meeting - Saturday, September 16, 2017 10a-4p Hermitage Library, 3700 James Kay Lane, Hermitage, TN 37076 Speaker: Dr. Theoharides, MD

  • • Brain Fires in Autism: Mast Cells, Microglia and Brain Inflammation - Hilton Orange County Hotel in Costa Mesa, BELIEVE room 2 – 8:00AM October 2017.
  • • Stress, Brain Inflammation and Brain Fog in Autism - Hilton Orange County Hotel in Costa Mesa, BELIEVE room 2 – 8:00AM October 2017
  • • Bari (Italy), 2nd European Conference of Biomedical Research and Treatments of Autism - Mast cell-microglia connection leading to focal inflammation of the brain in autism Saturday @ 15.40 - Brochure (PDF) November 2017
  • • Queen Mary University of London, 15:30-15:30-Regulatory systems pathway from stress to disease and possible parallels to periodontal disease Email: a.b.o.gamboa@qmul.ac.uk November 2017
  • • Queen Mary University of London, 15:30-16:00-Interventions on the immune regulatory systems Email: a.b.o.gamboa@qmul.ac.uk November 2017
  • • Conway Hall, London, 10:00 am, Brain Fires in Autism: Mast Cells, Microglia and Inflammation of the Brain December 2017
  • • Conway Hall, London, 10:00 am, Role of Mast Cells in Inflammatory Diseases December 2017

EAAACI=European Academy of Allergy and Clinical Immunology
ILADS=International Lyme and Associated Diseases Society
MAPS=Medical Academy of Pediatrics  Se-0pcial Needs
NCIMS=North Carolina Integrative Medical Society
TARF=The Autism Research Foundation
TACA=Think About Curing Autism
ILADS=International Lyme and Associated Diseases Society



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18 Social Skills Activities for Kids with Autism and Sensory Issues

Home of the Low Histamine Chef - Jasmina Ykelenstam




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