research

Pharmacology is the core of translational research leading to ways of alleviating disease. We study how mast cells are involved in allergy and inflammation. We showed that mast cells are activated by CRH and neurotensin secreted under stress to release inflammatory molecules selectively, including mitochondrial DNA ("innate pathogen") leading to disruption of the gut-blood-brain barriers and to inflammation. We have also shown that the flavonoid luteolin is inhibitory, and a patented liposomal formulation NeuroProtek®, benefits patients with allergies, autism and chronic fatigue syndrome.

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recent publications

Here you will find over 100 publications from the Theoharides’ Lab relevant to his research in Pharmacology and Drug Development.

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Awards & Honors

Awards and honors for Dr. Theoharides.

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video presentations

A look into Dr. Theoharides’ lectures or interviews on various topics.

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Lecture Slides

Follow along copies of slides Dr. Theoharides has lectured with.  Some may be used in conjunction with video lecture presentations or guides for research.

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Clinical studies

Papers on past and present clinical studies.

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Testimonials &
Useful Links

Kind words for Dr. Theoharides and his work.

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Featured presentation

AUTISM - A Pharmacologist's View.


 

Learn more about T. C. Theoharides, MS, PhD, MD, FAAAAI

New "innate pathogens" discovered by Dr. Theoharides (PDF)

 

Recent News Media

Greek Newspaper Article 2017 (PDF)

 

Greek Newspaper Article 2016 (PDF)

 

Groundbreaking Research Links Autism with Histamine, Inflammation and Mast Cell Activation. Read Article

 

Congratulations to Dr. Theoharides! The book Neuroimmune Pharmacology has recently been published in electronic and print format. Dr. Theoharids contributed to the Autism Spectrum Disorders portion of the book.

 

•• Dr. Theoharides paper "Neurotensin stimulates NTR3/sortilin and mTOR in human microglia: Potential therapeutic target in autism inhibitable by methoxyluteolin" has published online at www.pnas.org.

 

•• Dr. Theoharides selected to be included in "Famous Greeks"

 

•• Article on Dr. Theoharides' work on "BrainFog" in the Greek paper VIMA TIS KYRISKIS-SUNDAY SCIENCE edition (July 17, 2016)

 

•• Luteolin for mast cells, histamine and brain fog?

 

•• A wonderful plant supplement has been backed by scientific research as a mast cell stabiliser and antihistamine.

••  Hope For Autism - The National Herald

••  Autism Spectrum Programs at The Boston Conservatory

•• National Psoriasis Foundation - News Article

 

Videos

My mystery symptoms and mast cells (documentary)

 

 

ARI-Brain Allergy and Autism

 

 

AutismOne 2016-An Autism Subgroup With Brain Inflammation Is Treatable

 

 

Interview with Dr. Theoharides on GREEK NATIONAL TV DIPLI MATIA on Autism and Brain Fog

 

 

Interview with Dr. Theoharides on CNN.gr on Brain Inflammation

 

 

Radio Presentations

Interview of Dr. Theoharides by Mary Ann Rousso to The BlockTakRadio/Coffee Klatch/Special Needs Radio on Mast Cell Disorders.

 

Interview of Dr. Theoharides on intelligent radio by Dr. Hoffman on the benefits of luteolin.

upcoming events
16September

Nashville Support Group Meeting - Saturday, September 16, 2017
10a-4p Hermitage Library, 3700 James Kay Lane, Hermitage, TN 37076
Speaker: Dr. Theoharides, MD

 

 

21October

Brain Fires in Autism: Mast Cells, Microglia and Brain Inflammation
Hilton Orange County Hotel in Costa Mesa, BELIEVE room 2 – 8:00AM

 

 

22October

Stress, Brain Inflammation and Brain Fog in Autism
Hilton Orange County Hotel in Costa Mesa, BELIEVE room 2 – 8:00AM

 

 

11November

Bari (Italy), 2nd European Conference of Biomedical Research and Treatments of Autism - Mast cell-microglia connection leading to focal inflammation of the brain in autism
Saturday @ 15.40
Brochure (PDF)

 

 

30November

Queen Mary University of London,
15:30-15:30-Regulatory systems pathway from stress to disease and possible parallels to periodontal disease
Email: a.b.o.gamboa@qmul.ac.uk

 

 

30November

Queen Mary University of London,
15:30-16:00-Interventions on the immune regulatory systems
Email: a.b.o.gamboa@qmul.ac.uk

 

 

01December
02December

Conway Hall, London, 10:00 am,
Role of Mast Cells in Inflammatory Diseases

 

 

Prof. Theoharides' Invited Lectures (2015-16)

  • • Australia Autism Lecture (April 24, 2015; Melbourne, Australia)
  • • Boston Conservatory of Music (May 5, 2015; Boston, MA)
  • • Autism Education Summit (September 26, 2015; Dallas, TX)
  • • National Autism Association (October 15, 2015; St. Pete, FL)
  • • Autism Research Institute (December 5, 2015; Boston, MA, 2015)
  • • Cyprus Pediatric Association (February 14, 2016; Nicosia, CY)
  • • TARF Think Tank (February 19, 2016; Boston, MA)
  • • NCIMS (February 27, 2016;Greenboro, NC)
  • • TACA Massachusetts (March 12, 2016; Watertown MA)
  • • 11th PanHellenic Conference on Allergy & Clinical Immunology (April 16, 2016; Athens, Greece)
  • • TACA Webinar (April 25, 2016; 1 pm)
  • • All Childrens Hospital (April 1, 2016; St. Pete, FL)
  • • TACA Philadelphia (May 7, 2016; Philadelphia, PA)
  • • Autism One (May 27, 2016; Chicago, IL)
  • • Autism One Think Tank (May 28, 2016; Chicago, IL)
  • • EAAACI (June 7-11, 2017; Vienna, Austria)
  • • Old North State Medical Society (June 23-25, 2016; Raleigh, NC)
  • • FASEB Summer Research Conference in the long-running Neuroimmunology series entitled "Translational Neuroimmunology: From Mechanisms to Therapeutics" (July 24-29, 2016; Big Sky, MT)
  • • 11th Annual USAAA World Autism and Asperger Conference (August 29, 2016; Louisville, KY)
  • • MAPS Conference (September 9, 2016; Atlanta, GA)
  • • The Mastocytosis Society (September 15-17, 2016; Orlando, FL)
  • • International College of Geriatric Psychoneuropharmacology (ICGP) (October 7, 2016; Athens, Greece)
  • • TACA National Conference (October 22, 2016; Costa Mesa, CA)
  • • ILADS Annual meeting (November 4, 2016; Philadelphia, PA)
  • • 37th UMEMPS (Union of Middle-Eastern and Mediterranean Pediatric Societies-Cyprus Pediatric Society (November 6, 2016; Limassol, Cyprus)
  • • 1st International Conference on Autism (November 22, 2016; Paphos, Cyprus)

EAAACI=European Academy of Allergy and Clinical Immunology
ILADS=International Lyme and Associated Diseases Society
MAPS=Medical Academy of Pediatrics  Se-0pcial Needs
NCIMS=North Carolina Integrative Medical Society
TARF=The Autism Research Foundation
TACA=Think About Curing Autism
ILADS=International Lyme and Associated Diseases Society


 

 

 

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